This paper discusses some of the impacts attributed to climate change that are likely to hit Southern Africa as a result of increasing global greenhouse gas emissions into the atmosphere. As South Africa is a significant contributor to greenhouse gas emissions and currently ranked first in Africa, the paper assesses the country.s greenhouse gas emissions profile and possible future projections of emissions and their implications. It then discusses the strategic interventions proposed by South Africa in reducing the gap in emissions between what is required by science and what would happen if development continues at current rates without abating greenhouse gas emissions. Given that the majority of emissions are a result of energy consumption, the paper provides practical solutions to themes such as energy efficiency mostly for the industrial and commercial sectors. With international treaties on the reduction of greenhouse gas emissions (e.g. Kyoto protocol), there are business opportunities in the area of climate change mitigation. Thus, the paper finally discusses the Clean Development Mechanism (CDM) scenario in South Africa and how the country can benefit from other emission trading schemes being practiced in different regions of the world.