Gender imbalance among various streams of professionals is a constant cause of concern to policy planners and institution builders. The situation becomes more serious when we notice that girls often perform much better academically at secondary school level and then there is a sharp decline in their performance at graduate and postgraduate levels. The situation in the field of science and technology is no less serious. There are very few scientific institutions, which have women scientists as directors, or senior leaders of programmes. In this paper, we compare our insights from the formal scientific sector with our investigations in informal scientific sector. The effort to blend excellence in formal and informal scientific sectors would require overcoming the gender imbalances in both these sectors. A review of the current status and offer of some policy and institutional suggestions are also included, which could help in overcoming asymmetry in the knowledge and power of women in formal and informal sciences.