Interfirm collaboration and exchange relationships are fundamental to how value is created, managed, and exchanged between firms. In this paper we first identify three major research themes (nature, governance, and outcomes) that existing research has focused on and then propose three structural shifts (technology, platforms, and globalization) that might influence nature, governance, and outcomes associated with interfirm collaboration. We also synthesize a research agenda for the future and develop multiple research propositions that might become the foundation to integrate the structural shifts into research on interfirm collaboration. We provide guidance on how existing theories can help scholars address new research questions arising due to the structural shifts. Finally, we provide insights to managers on the type of data that they need to access to make more effective decisions related to interfirm collaboration in a dynamic business environment.